pharmacodynamics相关论文
抗菌药物的药代动力学/药效动力学研究充分考虑宿主、病原体和药物三者的相互关系，反映抗菌药物疗效及不良反应与药物浓度变化之间......
Anti-Inflammatory and Immunoregulatory Effects of Yupingfeng (玉屏风) Powder on Chronic Bronchitis Rats
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PHARMACOKINETICS AND PHARMACODYNAMICS STUDY OF RECOMBINE HUMAN GLUCAGON-LIKE PEPTID-1(7-36)IN HEALTH
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Research of pharmacodynamics and mechanism of ChaiQingxiaopi Capsule on hyperplasia of mammary gland
Aim: To study the therapentic effect of ChaiQingxiaopi Capsule (CQC) on the hyperplasia of mammary glands (HMG) in rats ......
Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Qishe Pill in Healthy Chinese Subject
To assess pharmacokinetics, pharmacodynamics, tolerability and safety of oral medication of Qishe Pill, a compound tradi......
Identification of PEAR1 single-nucleotide polymorphisms and their influences on the variation in Pra
Aim: The platelet responses to antiplatelet drugs are highly variable.However,the associated mechanisms are poorly defin......
A genome-wide association study identifies novel genetic loci modifying pharmacokinetic-pharmacodyna
Aim Clopidogrel therapy is associated with a substantial variability in pharmacokinetics (PK) and pharmacodynamics (PD) ......
Aim: To observe whether antithrombin agents affects the pharmacokinetic and pharmacodynamic properties of batifiban in c......
A genome-wide association study identifies novel genetic loci that modify pharmacokinetic-pharmacody
OBJECTIVE Genetic variants in the pharmacokinetic (PK) mechanism are the main underlying factors that modify the antipla......
Research of pharmacodynamics and mechanism of ChaiQingxiaopi capsule on hyperplasia of mammary gland
Aim: To study the therapentic effect of ChaiQingxiaopi capsule (CQC) on the hyperplasia of mammary glands (HMG) in rats ......
The comparison of the main pharmacodynamic effects between L.macranthoides Hand.-Mazz and Lonicera j
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For the Chinese people, dose the dosage of administration need to adjust? A phase I study of PEG-rhG
Objective Chemotherapy-induced neutropenia (CIN) is one of the major toxicities in cancer patients subjected to chemothe......
A genome-wide association study identifies novel genetic loci modifying pharmacokinetic-pharmacodyna
Clopidogrel therapy is associated with a substantial variability in pharmacokinetics (PK) and pharmacodynamics (PD) resp......
Injectable chitosan thermogels for sustained and localized delivery of Pingyangmycin in vascular mal
Pingyangmycin hydrochloride (PYM) is an effective sclerosing agent to treat vascularmalformations(VM), but can easily di......
Construction and anti-tumor mechanism of novel polymeric micelles for targeted intracellular drug de
Objective: The aim of our study is to develop novel polymeric micelles to achieve specific tumor targeting and rapid int......
Population Pharmacokinetic/Pharmacodynamic Model for C.E.R.A.in Both ESA-Na(i)ve and ESA-Treated Chr
This study aimed to develop a population pharmacokinetic/pharrnacodynamic (PK/PD) model for C.E.R.A., a continuous eryth......
Population Pharmacokinetic/Pharmacodynamics Modeling and Safety/Tolerability Assessing of Qishe Pill
Purpose:To assess pharmacokinetics,pharmacodynamics,tolerability and safety of oral medication of Qishe Pill in healthy ......
Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Qishe Pill in Healthy Chinese Subject
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Improvement the bioavailability of inadequate aqueous agent Herpetrione by sodium deoxycholate phosp
Herpetrione(PEDX),extracted from Herpetospcrmum caudigerum,is a novel and potent antiviral agent having hepatprotection ......
Development of Pharmacodynamic Models with Genes Expression to Evaluate the Target Drug Delivery Sys
With the advance of pharmaceutical manufacture technology and the development of the novel pharmaceutical excipients......
目的：比较罗库溴铵和琥珀胆碱的药效动力学以及用于气管内插管的效果。方法：成年全麻手术患者６０例随机分为四组，分别给予２或３倍ＥＤ９５罗库溴铵（Ｉ组......
目的:通过对微乳处方的筛选和优化,确定平胃微乳的处方组成,并进行药效学验证.方法:通过单因素考察,确定混合挥发油、药渣水提物及......
目的:应用群体药理学方法探讨血浆中乙醇浓度对β-羟丁酸,乙酰乙酸,乳酸,丙酮酸,β-羟丁酸/乙酰乙酸(H/A)比值及乳酸/丙酮酸(L/P)......
目的 在中国健康受试者中,进行常规型重组人胰岛素重和林TMR和优泌林@R的人体药代动力学、药效动力学研究,并评价两种制剂的生物等......
目的进行重组人胰岛素40/60混合注射液的药代、药效动力学研究，并与重组人胰岛素30/70混合制剂、常规型胰岛素、中性鱼精蛋白胰岛素......
目的 探讨中国健康受试者细胞色素P(CYP)2B6*6基因多态性对丙泊酚药代动力学和药效学的影响.方法 20例男性健康受试者单次静脉注射......
目的:阐明健康志愿受试者经单次和多次餐时口服盐酸伊伐布雷定片后,原型药伊伐布雷定、代谢产物去甲伊伐布雷定(S-18982)的体内动......
Characteristics and therapeutic efficacy of sulfasalazine in patients with mildly and moderately act
AIM: To investigate the characteristics and short-term efficacy of sulfasalazine (SASP) in patients with mildly and mode......
Pharmacodynamic and kinetic effect of rabeprazole on serum gastrin level in relation to CYP2C19 poly
AIM: To observe the pharmacokinetics and pharmacodynamics of rabeprazole and compare serum gastrin concentrations in dif......
目的探讨何首乌不同溶剂提取物在治疗糖尿病方面是否具有药效学优势,比较不同溶剂对糖尿病及其并发症的影响。方法高脂饲料喂养联......
目的在比格犬中建立高胰岛素-正葡萄糖钳夹技术。方法以5只健康比格犬为实验对象进行高胰岛素-正葡萄糖钳夹实验,考察血糖、胰岛素......
Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae.Plants from genus Kadsura are widely distributed in the......
目的对甲巯咪唑水凝胶贴剂治疗甲状腺功能亢进症(甲亢)的药效学进行研究。方法通过灌服甲状腺片进行Wistar大鼠甲亢造模,药效学实......
目的 探讨复方硫磺软肝丸对改良方法所致大鼠慢性肝纤维化模型的保肝及抗纤维化作用.方法 采用配方饲料加腹腔注射CCl4橄榄油溶液......
巴洛沙韦是一种聚合酶酸性(PA)内切核酸酶抑制剂,于2018年10月25日由美国FDA批准上市,用于治疗12岁及以上无并发症的流感患者.本文......
目的研究CYP2C19基因多态性对奥美拉唑在中国人体内的药物动力学和药效学的影响.方法在18例幽门螺杆菌感染阴性的健康志愿者中,应......
目的:考察抗病毒蛋白Ⅰ期临床试验受试者的2’,5’-寡聚腺苷酸合成酶水平,初步评价抗病毒蛋白乐复能的药效学特性.方法:采用2’,5......
烟草中所含的多环芳香烃和尼古丁等物质能通过多种途径影响抗肿瘤药物的药动学和药效学参数,改变药物在体内的清除率和系统暴露量,......
目的研究地塞米松(Dex)高分子前药(P-Dex)对佐剂性关节炎(AIA)大鼠的疗效及其组织分布。方法于大鼠后足跖皮内注射完全弗氏佐剂建......
目的 优化亚胺培南在接受连续性静脉-静脉血液滤过(CVVH)治疗的不同程度肾功能损害的多器官功能障碍综合征(MODS)患者中的给药方案......
目的 综述新一代抗菌药物Dalbavancin的最新研究进展. 方法 通过检索Google Scholar以及Science Direct查阅大量近10年的相关文献,......
目的 比较2％与1％丙泊酚的实际药效关系, 减少丙泊酚麻醉患者脂质输入过多引起的相关不良反应.方法 择期行腹腔镜子宫肌瘤剔除术患者8......
器官移植是救治器官功能衰竭最有效的手段,但术后急、慢性排斥反应是导致移植物功能丧失的重要原因之一,因此免疫抑制剂的安全合理......
研究mPEG-ALD修饰CPU-HM的反应条件并对修饰产物的体内药效进行初步筛选。采用正交试验法,利用HPLC的面积归一化法检测各修饰条件......
,Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotype in h
Aim: To investigate whether the pharmacodynamics and pharmacokinetics of rabeprazole are dependent on CYP2C19 genotype s......
Aim: The relative bioavailabilities and effects on lung injury alleviation of 4 insu-lin-artificial pulmonary surfactant......
